The No. 18 Ole Miss Rebels will return from their bye week when they host the struggling Oklahoma Sooners on Saturday afternoon. Ole Miss opened the season with a four-game winning streak, but it has lost two of its three games since then. Oklahoma has lost three of its last four games, including a 35-9 loss to South Carolina last week. 

Kickoff is set for noon ET on Saturday at Vaught-Hemingway Stadium at Hollingsworth Field. Ole Miss is favored by 20 points in the latest Ole Miss vs. Oklahoma odds, while the over/under is 49.5 points, per SportsLine consensus. Before entering any Oklahoma vs. Ole Miss picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 14-7 on all top-rated picks over the past four weeks of this season. Anyone following has seen STRONG returns!

The model has simulated Ole Miss vs. Oklahoma 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60% of simulations!

So who wins Ole Miss vs. Oklahoma, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!